Senior Scientist I - CMC BioProcess Purification Development

Location: South San Francisco
Posted on: June 23, 2025

Job Description:

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok . Job Description The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure.This role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20 novel biologics and successfully filed two BLAs. As one of CMC purification development group members, you will apply your strong expertise in CMC purification to develop robust, phase-appropriate processes for drug substance GMP production to enable human clinical studies and eventual licensure. You will be responsible for all aspects of CMC purification program deliverables and help drive drugs substance purification development strategy though program lead assignments in cross-functional CMC teams. This position is an onsite role in a lab-based function. To be successful candidates must enjoy and thrive in an onsite, highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists. Responsibilitiesinclude: Development, optimize, and scale-up purification processes for biologics candidates to support early and late stagedevelopment Transfer processes to GMP manufacturing for clinical material production Work with contract labs and carry out viral clearancestudies Conceive and evaluate novel, advanced bioprocess technologies that are in line with the groups strategy Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overallprogram Seize opportunities to pursue project relevant leads that are in line with the groups strategy Maintain a high level of productivity in the lab Write technicalpublications,reports, presentations, and regulatory filingsincluding publishingresearch in peer-reviewed journals and presentingwork at scientificconferences Workefficiently,collaboratively,and cross-functionally toward project timelines and goals Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, and GxP compliance, where applicable Participate oncross-functional projectteams Mentor and train junior scientists Qualifications Minimum Qualifications: Degree in Chemical Engineering, Biochemistry, Chemistry or other sciences Bachelors degree 10 or moreyears of experience OR Masters 8 or more years of experience, OR a PhD Must have CMC protein purification experience with standard bioprocess unit operations such as chromatography separations and filtration Preferred Qualifications: Proficient in writing methods and operatingAKTA chromatographic instruments (such as AKTA Avant, AKTA Purifier, AKTA Pure, AKTA Readyor similar) Has a strong understanding of analytical techniques, such as HPLC andELISA Has hands on experience with monoclonal antibody or antibody-like molecule purification process development at laboratory, pilot and/orGMP scale Proven experience in mechanistic modeling of downstream purification unit operations including chromatography separations and/or membrane separations Other Required Skills: Ableto independently design, execute, use and reference literature publications, and interpret laboratory experimentsto answer scientificquestions Able to manage and organize large data sets to help interpret results using data visualization tools Must be forward-thinking and be able to lead and contribute to scientific/technicaldiscussionsand innovation Abletoindependentlylearn, understand and executenovel, advancedscientifictechniques Must haveexcellent attention to detail and ability to keep detailed writtenrecords Proven record of authoring publications, technical reports, regulatory documents, and/orpresentations Hasstrong communicationskills includingverbal, written,andscientific datapresentation Has excellentunderstanding ofbiochemistryandbioprocess engineeringconcepts Ableto work collaboratively within and outside of thegroup Hasproficiencywith Microsoft Office software, ability to learn new softwareapplications Has a strong understanding of statisticalanalysis Demonstrated scientific aptitude through authorship of peer-reviewedpublications Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

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