Scientist, Chemical Development
Location: South San Francisco
Posted on: June 23, 2025
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Job Description:
Alumis Inc. is a precision medicines company with the mission to
transform the lives of patients with autoimmune diseases. Even with
treatment innovations of the last two decades, many patients with
immunologic conditions continue to suffer - our goal is to
fundamentally change the outcomes for these patients. The Alumis
team is seeking a highly motivated Scientist, Chemical Development
to join the Technical Operations / Chemistry, Manufacturing, and
Controls (CMC) team at Alumis. The successful candidate will
support process development efforts as well as oversee activities
at contract research organizations (CROs) and contract development
and manufacturing organizations (CDMOs). RESPONSIBILITIES Perform
experiments in the synthesis, purification, and characterization of
small molecules as a part of process investigation, quality by
design (QbD) process development, and optimization Review and
approve cGMP documents, including batch records, change controls,
deviations, specifications, validation master plan, and validation
protocols/reports Support external CDMO activities for drug
substance development and manufacturing, including tech transfer,
scale-up, process development, and optimization Assist in the
generation of regulatory filings, including IND/IMPDs and NDA/MAAs
Document development activities as source reports for regulatory
filings Work effectively with the cross-functional CMC teams to
ensure timely delivery of drug substance throughout the full drug
lifecycle Implement best practices and drive continuous
improvements in the drug substance development process through
technology innovation and problem solving Proactively identify
risks and communicate effectively to functional teams across all
levels of the organization Track progress against project
timelines, generate regular status updates, and communicate
progress and issues to management, including presentation of
findings at team meetings THE IDEAL CANDIDATE PhD/MS with 3 years
of experience in chemistry or pharmaceutical sciences is desirable
Hands-on experience in working in the lab to independently solve
process chemistry issues is highly desired Experience with control
strategy development and capable of utilizing QbD principles to
develop commercially viable manufacturing processes Knowledge of
cGMP, ICH, and regulatory requirements Highly proficient oral and
written communication abilities Strong presentation skills highly
desired Excellent collaboration, problem-solving, and
organizational skills Comfortable in a fast-paced, small company
environment Ability to travel domestically and internationally up
to 25% of the time to support ongoing manufacturing activities
EDUCATION PhD/MS in Organic Chemistry, or related field The salary
range for this position is $140,000 USD to $150,000 USD annually.
This salary range is an estimate, and the actual salary may vary
based on the Company’s compensation practices. This position is
located in South San Francisco, CA and employees are expected to be
onsite Tuesday-Thursday. Lab personnel, however, are generally
onsite 4-5 days/week. At this time we are not considering remote
applicants. Alumis Inc. is an equal opportunity employer. Alumis
compensation packages include generous stock option grants for all
employees as well as an annual bonus program. Other benefits
include: Health insurance premiums paid at 90% for employee, 80%
for dependents Free access to Genentech Bus & Ferry Share program
$100 monthly cell phone stipend Unlimited PTO for Exempt employees
Free onsite gym and a kitchen stocked with yummy snacks and drinks!
We are a hard-working, collaborative team on a mission to transform
patient’s lives and we aspire to elevate , challenge and nurture
one another along the way.
Keywords: , Santa Rosa , Scientist, Chemical Development, Science, Research & Development , South San Francisco, California
