Principal Scientist - Functional Genomics

Location: South San Francisco
Posted on: June 23, 2025

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist - Functional Genomics What you will do Lets do this. Lets change the world. In this vital role you will join an enthusiastic, fast-paced team utilizing cutting functional genomics to advance target discovery, validation, and progression across Amgens therapeutic areas. Lead impactful functional genomics efforts for target discovery and validation Identify and implement new and innovative technologies to accelerate discovery Be at the forefront of integrating insights from multimodal data spanning human genetics, disease profiling, and perturbation studies Collaborate closely with human genetics, disease area, computational biology, and therapeutic development colleagues to formulate and deliver impactful projects Make actionable decisions as a technical and intellectual subject matter expert Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums Basic Qualifications: Doctorate degree and 2 years relevant experience OR Master's degree and 5 years of relevant experience OR Bachelor's degree and 7 years of relevant experience Preferred Qualifications: Doctorate degree in genetics, genomics, cell and molecular biology, systems biology, or related disciplines Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant contributions to discovery programs and publications in top tier journals Hands-on expertise conducting and delivering complex functional genomics screening campaigns for discovery, including coupling perturbation screens with single cell multiomics Strong expertise with genomic assays and experience with cutting edge profiling techniques Strong expertise on prosecuting insights from human genetics along with approaches for in depth biological study of potential targets Proficiency in programming (e.g. in R/Python), Unix/Linux environments, and cloud computing environments for the analysis of large omics datasets and generation of custom computational pipelines Proficiency with experimental design, data generation, and analysis principles across a broad range of omics technologies and assays, including single cell Strong written, verbal, and oral communication skills and ability to thrive in cross-functional settings Experience in managing and coordinating team efforts What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: , Santa Rosa , Principal Scientist - Functional Genomics, Science, Research & Development , South San Francisco, California