Associate Director, Toxicology

Company: Revolution Medicines
Location: Redwood City
Posted on: April 14, 2025

Job Description:

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.The Opportunity:In anticipation of the Company's growth plans, we are seeking an experienced Toxicologist to lead safety strategies for small molecule discovery programs and work in close collaboration with colleagues in Research and Development to enable the advancement of portfolio programs. The ideal candidate will deliver a balanced assessment of the risk/benefit profile associated with a drug candidate by integrating pharmacology/toxicology studies and engaging with stakeholders to align on a tractable clinical development plan. Further, the ideal candidate will:

• Function as a project toxicologist on drug discovery and development multidisciplinary teams and be a strong advocate for patient safety.
• Design and execute nonclinical toxicology strategies to advance pipeline of small molecule cancer therapeutics through all phases of research clinical development, including target de-risking, screening, issue mitigation and investigation of toxicities observed in vivo.
• Effectively implement and oversee studies outsourced to CROs, in close collaboration with study operations, pharmacology, DMPK and clinical pharmacology groups.
• Analyze, interpret, and summarize nonclinical safety data, and present contextualized findings and recommendations to internal project teams and leadership.
• Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making, including drafting and review of nonclinical sections of regulatory documents.
• Assist in the preparation of occupational toxicology documents, including occupational exposure limits (OELs), occupational health (hazard) categorizations (OHCs), and safety data sheets (SDSs), as well as product safety documents including permitted/acceptable daily exposure (PDE) assessments for products and impurities.Required Skills, Experience and Education:
• Ph.D. degree in toxicology, pharmacology or related discipline with 5+ years, or M.S. degree with 10+ years of relevant biotech/pharma drug discovery/development experience in a team-facing roles; DABT certification is desirable.
• Experience preparing nonclinical safety sections supporting IND/NDA submissions using CTD format.
• Interactions with FDA and other regulatory agencies.
• A thorough understanding of GLP regulations as well as US and ex-US regulatory guidance documents.
• Experience with small molecules; prior experience with targeted oncology therapeutics and late-stage development highly desirable.
• Strong scientific background and scientific aptitude with excellent critical thinking skills.
• Ability to work effectively and collaboratively on cross-functional project teams; demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute goals as a member of an interdisciplinary team is extremely important.
• Excellent verbal, presentation and written communication skills.
• Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, small company environment.Preferred Skills:
• Previous work in impurity assessment, product quality, occupational toxicology, or in silico/computational toxicology.
• Prior experience with development of oncology therapeutics.The base salary range for this full-time position is $164,000 to $205,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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Keywords: Revolution Medicines, Santa Rosa , Associate Director, Toxicology, Executive , Redwood City, California